S100A7 Antibody | 1A4

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S100A7 Antibody | 1A4 gallery image 1

Western Blot analysis of S100A7 expression in A-431 using Mouse anti Human S100A7 (MCA5253Z)

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S100A7 Antibody | 1A4 gallery image 2

Immunofluorescence showing S100A7in A-431 cells using Mouse anti Human S100A7 (MCA5253Z)

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  • Mouse anti Human S100A7:Preservative Free
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Monoclonal Antibody
  • Clone
    1A4
  • Isotype
    IgG1
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA5253ZIF, WBdatasheet pdfdatasheet pdf0.1 mg
    MCA5253Z
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Mouse anti Human S100A7 antibody, clone 1A4 recognizes human Protein S100-A7, also known as psoriasin or S100 calcium-binding protein A7. Psoriasin is a 100 amino acid secreted host defence peptide (Kesting et al. 2010). Host defence peptides (HDPs) are endogenous antimicrobial paptides produced principally by epithelia and up-regulated in inflamed epithlial tissues responding to immunological insult. Psoriasin is a ~11kDa peptide, as shown by Western blotting under reducing conditions.

      HPDs are a large diverse group of peptides produced by a vast array of both invertebrate and vertebrate organisms. In humans many such peptides exist including the defensins and calthecidins, all having innate anti-microbial properties which act as natural antibiotics or modulate the host immune response to microbial invasion. Production of HPDs can be stimulated either directly by microbial products such as endotoxin or by the presence of host pro-inflammatory cytokines.

      S100A7 was first identified in epidermal cells affected by the auto-immune condition psoriasis (Watson et al. 1998). S100A7 is expressed in the nucleus and cytoplasm of basal epidermal cells but is associated with the plasma membrane in spinous epidemal cells. It is markedly over-expressed in psoriatic tissues (Broome et al. 2003).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunofluorescence0.110 ug/ml
      Western Blotting0.110 ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional S100A7 Antibody Formats

    Formats Clone Applications Sizes available
    S100A7 Antibody : Preservative Free 1A4 IF, WB 0.1 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              References

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