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Proliferation Associated Protein 2G4 antibody | OTI1D3

Mouse anti Proliferation Associated Protein 2G4

Product Type
PrecisionAb Monoclonal
Clone
OTI1D3
Isotype
IgG1
Format
Purified
Specificity
Proliferation Associated Protein 2G4

Product Code Applications Pack Size List Price Your Price Qty
VMA00111
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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loader

Mouse anti Human proliferation associated protein 2G4 antibody recognizes proliferation associated protein 2G4, also known as ErbB-3 binding protein 1, ErbB3-binding protein Ebp1, cell cycle protein p38-2G4 homolog and erbB3-binding protein 1.

Proliferation associated protein 2G4, encoded by the PA2G4 gene, is an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. It is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. PA2G4 has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified (provided by RefSeq, Jul 2008).

Mouse anti Human proliferation associated protein 2G4 antibody detects a band of 44 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti proliferation associated protein 2G4 detects a band of approximately 44 kDa in HeLa cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
1% Bovine Serum Albumin.
50% Glycerol.
Immunogen
Full length recombinant human proliferation associated protein 2G4 (NP_006182) produced in HEK293T cells
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q9UQ80
Entrez Gene
PA2G4
GO Terms
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0030529 ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0005730 nucleolus
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0007050 cell cycle arrest
GO:0008283 cell proliferation
GO:0031625 ubiquitin protein ligase binding
GO:0045892 negative regulation of transcription, DNA-dependent

VMA00111

240615

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