PRESENILLIN-1 Antibody (PrecisionAbTM Antibody)

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PRESENILLIN-1 Antibody (PrecisionAb<sup>TM</sup> Antibody) gallery image 1

Western blot analysis of whole cell lysates probed with presenillin-1 antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 299 second exposure. Arrow points to presenillin-1 (molecular weight 55 kDa)

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  • PRESENILLIN-1 Antibody (PrecisionAb<sup>TM</sup> Antibody) thumbnail image 1
  • Presenilin-1 Antibody with Control Lysate
  • Presenilin-1 Antibody with Control Lysate
  • Rabbit anti Presenilin-1
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    Rabbit anti human presenillin-1 antibody recognizes the presenillin-1 protein, also known as PS-1. This antibody has been extensively validated for western blotting using whole cell lysates.
    • Product Type
      PrecisionAb™ Polyclonal
    • Isotype
      Polyclonal IgG
    • Format
      Purified
      Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
      VPA00332WBdatasheet pdfdatasheet pdf100 µl
      VPA00332
      VPA00332KWBdatasheet pdfdatasheet pdf datasheet pdf10 Westerns
      VPA00332K
      VPA00332KTWBdatasheet pdfdatasheet pdf datasheet pdf2 Westerns
      VPA00332KT
      Summary
      Secondary Antibodies
      Negative Isotype Controls
      Useful Reagents
      Positive Controls
      Histology Controls
      References
      Reviews
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      • Rabbit anti Human presenilin-1 antibody recognizes presenilin-1 also known as PSEN1.

        Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (presenilin-1 or presenilin-2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for Presenilin-1, the full-length nature of only some have been determined (provided by RefSeq, Aug 2008).

        Rabbit anti Human presenilin-1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. This antibody is available with a positive control lysate, in a smaller trial size, and as a standalone antibody.
      • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000

      • PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
      • Copyright © 2016 Bio-Rad

      Recommended Secondary Antibody

        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Rabbit IgG (H/L):HRPSTAR208P2 mlWB
        STAR208P
        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Rabbit IgG (H/L):HRPSTAR208P2 mlWB
        STAR208P
        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Rabbit IgG (H/L):HRPSTAR208P2 mlWB
        STAR208P

        Recommended Negative Isotype Control

          Useful Reagents

            Recommended Positive Controls

              Histology Controls

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