Presenilin-1 Antibody

Presenilin-1 Antibody gallery image 1

Western blot analysis of human brain lysate with Rabbit anti Human presenilin-1 (AHP1497) at 0.5(A), 1(B) and 2(C) ug/ml

Presenilin-1 Antibody gallery image 2

Formalin fixed, paraffin embedded human brain with Rabbit anti Human presenilin-1 (AHP1497) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)

  • Presenilin-1 Antibody thumbnail image 1
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  • Rabbit anti Presenilin-1
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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP1497P*, WBdatasheet pdfdatasheet pdf0.1 mg
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Rabbit anti Human Presinilin-1 antibody recognizes human Presenilin-1, a 52.7 kDa membrane protein expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.

      Presenilin-1 was originally identified as a marker of susceptibility for familial early onset Alzheimer's disease type 3 (AD3). Presenilin-1, along with PEN2, Nicastrin and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. Cleavage of these proteins is a key step in signalling from several cell-surface receptors and is believed to be required for the generation of neurotoxic amyloid peptides that are central in the development of Alzheimer's disease.

      At least 6 isoforms of Presenilin-1 exist.

      Rabbit anti Human Presinilin-1 antibody (AHP1497) is specific for Presenilin-1 and shows no cross reactivity with Presenilin-2.
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting0.51.0ug/ml
      Immunohistology - Paraffin(1)2.5ug/ml
      This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
      Human brain
    • Immunofluorescence
    • Western Blotting
      AHP1497 detects a band of approximately 44kDa in human brain cell lysates.
    • Instructions For Use

    Additional Presenilin-1 Antibody Formats

    Formats Applications Sizes available
    Presenilin-1 Antibody : Purified P*, WB 0.1 mg
    • Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)

    Recommended Secondary Antibody

      DescriptionProduct CodePack SizeApplicationsList PriceQuantity
      Goat anti Rabbit IgG (Fc):BiotinSTAR121B1 mgE, WB
      Sheep anti Rabbit IgG:Biotin2AB02B1 mlC, E, P, WB
      Sheep anti Rabbit IgG:DyLight®488STAR36D488GA0.1 mgF, IF, WB
      Sheep anti Rabbit IgG:DyLight®549STAR36D549GA0.1 mgF, IF
      Sheep anti Rabbit IgG:DyLight®649STAR36D649GA0.1 mgF, IF
      Sheep anti Rabbit IgG:DyLight®680STAR36D680GA0.1 mgF, IF, WB
      Sheep anti Rabbit IgG:Dylight®800STAR36D800GA0.1 mgF, IF, WB
      Goat anti Rabbit IgG (Fc):FITCSTAR121F1 mgF
      Sheep anti Rabbit IgG:FITCSTAR34B1 mgC, F
      Goat anti Rabbit IgG (Fc):HRPSTAR121P1 mgE, WB
      Goat anti Rabbit IgG (H/L):HRPSTAR124P1 mgC, E, WB
      Sheep anti Rabbit IgG:RPESTAR35A1 mlF

      Recommended Negative Isotype Control

        Useful Reagents

          DescriptionProduct CodePack SizeApplicationsList PriceQuantity
          Antigen Retrieval Buffer, pH8.0BUF025C50 mlP
          TidyBlot™ Western Blot Detection Reagent:HRPSTAR209P0.5 mlWB*
          Antigen Retrieval Buffer, pH8.0BUF025A500 mlP

          Recommended Positive Controls

            Histology Controls

              Human brain

              Further Reading

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