Notch 1 Antibody | 4G1

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Notch 1 Antibody | 4G1 gallery image 1

Western Blot analysis of NOTCH 1 expression in Raw 264.7 using Mouse anti Human NOTCH 1 (MCA4804Z)

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  • Notch 1 Antibody | 4G1 thumbnail image 1
  • Mouse anti Human Notch 1:Preservative Free
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Monoclonal Antibody
  • Clone
    4G1
  • Isotype
    IgG1
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA4804ZWBdatasheet pdfdatasheet pdf0.1 mg
    MCA4804Z
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Mouse anti Human Notch 1 antibody, clone 4G1 recognizes human Neurogenic locus notch notch homolog protein 1, also known as Notch 1 or translocation-associated notch protein TAN-1. Notch 1 is a 2555 amino acid type 1 transmembrane glycoprotein with a predicted molecular mass of ~272 kDa including the 18 amino acid signal peptide. Notch 1 is involved in the regulation of cell fate determination by acting as a receptor for Jagged1, Jagged2 and Delta1.

      Mutations in the NOTCH1 gene can lead to the development of Aortic valve disease 1 (AOVD1), a common defect involving the loss of one of the 3 leaflets of the aortic valve (Garg et al. 2005). Mutations in the NOTCH1 gene can also lead to Adams-Oliver syndrome 5 (AOS5) a syndrome defined by the presence of aplasia cutis congenita of the scalp vertex and terminal transverse limb defects (Stittrich et al. 2014).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting0.110 ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Notch 1 Antibody Formats

    Formats Clone Applications Sizes available
    Notch 1 Antibody : Preservative Free 4G1 WB 0.1 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

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