NOD2 Antibody

NOD2 Antibody gallery image 1

Western blot analysis of whole cell lysate from HeLa cells probed with Rabbit anti Human NOD2 (AHP1015) at 2(A) and 4(B) μg/ml

NOD2 Antibody gallery image 2

Immunocytochemical staining of HeLa cells with Rabbit anti Human NOD2 (AHP1015)

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  • NOD2 Antibody thumbnail image 2
  • Rabbit anti Human NOD2 (C-Terminal)
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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP1015C, WBdatasheet pdfdatasheet pdf0.1 mg
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Rabbit anti Human NODs antibody recognizes NOD2, an intracellular protein of ~100 kDa, which belongs to the NOD (nucleotide binding oligomerisation domain) family. The NOD family comprises at present more than 20 different mammalian NOD-LRR (leucine-rich repeat) proteins, which are involved in the regulation of apoptosis and the immune response.

      NOD2 has been shown to be constitutively or inducibly expressed in monocytes, macrophages, T and B cells, dendritic cells, as well as intestinal epithelial cells. A specific motif of peptidoglycan (PGN), muramyl dipeptide (MDP), has been identified as the sole l

      NOD2 and Toll-like receptors (TLR) are emerging as key mediators of innate host defence in the intestinal mucosa, crucially involved in maintaining mucosal and commensal homeostasis.

      Mutations in the gene encoding NOD2 are a major susceptibility factor underlying a significant subgroup of patients with Inflammatory bowel disease 1 (IBD1), a disease characterized by chronic relapsing inflammation of the gastrointestinal tract, subdivided into Crohn disease and ulcerative colitis phenotypes (Hugot et al. 2001). Mutations can also lead to development of Blau syndrome (BLAUS) a rare autosomal dominant condition demonstrating early onset granulomatous arthritis, skin rash and uveitis (Parkhouse et al. 2014). Additionally mutations in this gene can lead to development of Early onset sarcoidosis (EOS) characterized by the formation of immune granulomas in affected organs, most often the lungs and lymphatics but often other organs can be involved (Okada et al. 2009).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Frozen
      Western Blotting24ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
      AHP1015 detects a band of approximately 100kDa in HeLa cell lysate.
    • Instructions For Use

    Additional NOD2 Antibody Formats

    Formats Applications Sizes available
    NOD2 Antibody : Purified C, WB 0.1 mg
    • Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)

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      Recommended Negative Isotype Control

        Useful Reagents

          DescriptionProduct CodePack SizeApplicationsList PriceQuantity
          TidyBlot™ Western Blot Detection Reagent:HRPSTAR209P0.5 mlWB*

          Recommended Positive Controls

            Histology Controls

              Further Reading

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