Myosin Heavy Chain 9 Antibody | 4H3

//www.bio-rad-antibodies.com/human-myosin-heavy-chain-9-antibody-4h3-mca5244z.html?RenderPageSpecific=1
Myosin Heavy Chain 9 Antibody | 4H3 gallery image 1

Staining of paraffin-embedded human ovary cancer with Mouse anti Human MYOSIN HEAVY CHAIN 9 (MCA5244Z)

Enlarge
  • Myosin Heavy Chain 9 Antibody | 4H3 thumbnail image 1
  • Mouse anti Human Myosin Heavy Chain 9:Preservative Free
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Monoclonal Antibody
  • Clone
    4H3
  • Isotype
    IgG2b
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA5244ZPdatasheet pdfdatasheet pdf0.1 mg
    MCA5244Z
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
    -
    • Mouse anti Human myosin heavy chain 9 antibody, clone 4H3 recognizes human myosin-9, also known as myosin heavy chain 9, Cellular myosin heavy chain; type A, Myosin heavy chain 9, Myosin heavy chain, non-muscle IIa, Non-muscle myosin heavy chain A, NMMHC-A or Non-muscle myosin heavy chain IIa. myosin-9 is a 1959 amino acid ~230 kDa cellular myosin playing an important role in cytoskeletal reorganization during cell spreading, also plays roles in cytokinesis, secretion and capping. Myosin-9 is highly expressed in the kidney glomeruli (Arrondel et al. 2002) and is expressed in leukocytes (Toothaker et al. 1991).

      Two isoforms of Myosin-9 produced by alternative splicing have been described. Mouse anti Human myosin heavy chain 9 antibody, clone 4H3 recognizes the canonical isoform 1. Binding to isoform 2 which has the n-terminal 5 amino acids of the immunogen used for the generation of clone 4H3 missing, has not been established (UniProt : P35579).

      Mutations in the MYH9 gene can lead to a number of thrombocytopenic disorders including May-Hegglin anomaly (MHA), Sebastian syndrome (SBS), Fechtner syndrome (FTNS), Alport syndrome, with macrothrombocytopenia (APSM) and Macrothrombocytopenia and progressive sensorineural deafness (MPSD). Mutations in the MHY9 gene can als lead to Deafness, autosomal dominant, 17 (DFNA17), a form deafness characterized by progressive high frequency hearing impairment and cochleosaccular degeneration (Lalwani et al. 2000).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Paraffin0.110 ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Myosin Heavy Chain 9 Antibody Formats

    Formats Clone Applications Sizes available
    Myosin Heavy Chain 9 Antibody : Preservative Free 4H3 P 0.1 mg
    • Copyright © 2016 Bio-Rad

    Recommended Secondary Antibody

      DescriptionProduct CodePack SizeApplicationsList PriceQuantity
      Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)STAR117A0.5 mgE, WB
      STAR117A
      Goat anti Mouse IgG/A/M:Alk. Phos.STAR87A1 mgC, E, WB
      STAR87A
      Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)STAR117D488GA0.1 mgF, IF
      STAR117D488GA
      Goat anti Mouse IgG (H/L):DyLight®549 (Multi Species Adsorbed)STAR117D549GA0.1 mgF, IF
      STAR117D549GA
      Goat anti Mouse IgG (H/L):DyLight®649 (Multi Species Adsorbed)STAR117D649GA0.1 mgF, IF
      STAR117D649GA
      Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)STAR117D680GA0.1 mgF, WB
      STAR117D680GA
      Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)STAR117D800GA0.1 mgF, IF, WB
      STAR117D800GA
      Rabbit F(ab')2 anti Mouse IgG:Dylight®800STAR8D800GA0.1 mgF, IF, WB
      STAR8D800GA
      Human anti Mouse IgG2b:FITCHCA038F0.1 mgF
      HCA038F
      Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)STAR117F0.5 mgF
      STAR117F
      Goat anti Mouse IgG:FITC (Rat Adsorbed)STAR700.5 mgF
      STAR70
      Goat anti Mouse IgG (Fc):FITCSTAR120F1 mgC, F
      STAR120F
      Rabbit F(ab')2 anti Mouse IgG:FITCSTAR9B1 mgF
      STAR9B
      Human anti Mouse IgG2b:HRPHCA038P0.1 mgE
      HCA038P
      Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)STAR117P0.5 mgE, WB
      STAR117P
      Goat anti Mouse IgG:HRP (Rat Adsorbed)STAR770.5 mgC, E, P
      STAR77
      Goat anti Mouse IgG (Fc):HRPSTAR120P1 mgE, WB
      STAR120P
      Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed)STAR13B1 mgC, E, P, RE, WB
      STAR13B
      Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)STAR87P1 mgE
      STAR87P
      Rabbit F(ab')2 anti Mouse IgG:RPESTAR12A1 mlF
      STAR12A
      Goat anti Mouse IgG:RPE (Rat Adsorbed)STAR761 mlF
      STAR76
      Human anti Mouse IgG2b:RPEHCA038PE100 TestsF
      HCA038PE

      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              Write your review

              You may also be interested in...