MED17 antibody
Rabbit anti MED17
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- MED17
Antibody Quality and Performance Guarantee
| Rabbit anti Human MED17 antibody recognizes MED17 also known as, mediator of RNA polymerase II transcription subunit 17, activator-recruited cofactor 77 kDa component, cofactor required for Sp1 transcriptional activation, subunit 6, thyroid hormone receptor-associated protein complex 80 kDa component, transcriptional coactivator CRSP77 or vitamin D3 receptor-interacting protein complex 80 kDa component. The activation of gene transcription is a multistep process triggered by factors that recognize transcriptional enhancer sites in DNA, these factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by MED17 gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors (provided by RefSeq, Jul 2008). Rabbit anti Human MED17 antibody detects a band of 95 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti MED17 detects a band of approximately 95 kDa in MCF7 cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the N terminal region of human MED17
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- Q9NVC6
- Entrez Gene
- MED17
- GO Terms
- GO:0004872 receptor activity
- GO:0005667 transcription factor complex
- GO:0006367 transcription initiation from RNA polymerase II promoter
- GO:0016455 RNA polymerase II transcription mediator activity
- GO:0016563 transcription activator activity
- GO:0016592 mediator complex
- GO:0046966 thyroid hormone receptor binding
- GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
- GO:0030521 androgen receptor signaling pathway
- View More GO Terms
- GO:0042809 vitamin D receptor binding
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
VPA00478
160712
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