MCM6 Antibody

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Detection of human MCM6 in a RIPA extract of HeLa cells by Western Blotting using Rabbit anti Human MCM6 (AHP841)

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  • Rabbit anti Human MCM6
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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP841WBdatasheet pdfdatasheet pdf0.1 mg
    AHP841
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
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    References
    Reviews
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    • Rabbit anti Human MCM6 antibody recognizes human DNA replication licensing factor MCM6, also known as minichromosome maintenance 6 (MCM6) or p105MCM. MCM6 is a 821 amino acid, ~115kDa nuclear component of the MCM complex containing a single MCM domain.

      MCM6 is involved in the initiation and control of eukaryotic DNA replication. Studies show that MCM4 forms a hexameric protein complex with MCM6 and 7, which has DNA helicase activity, and may act as a DNA unwinding enzyme (Kanter et al. 2008). The phosphorylation of this complex by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex (Ishimi et al. 2001).

      MCM6 has been noted to have elevated expression in Hodgkin's lymphoma (Karimi et al. 2008) and be a predictor of survival in patients with mantle cel lymphoma (Schrader et al. 2005).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunoprecipitation
      Western Blotting1/20001/10000

    • Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
      AHP841 detects a band of approximately 105 kDa in HeLa cell lysates.
    • Instructions For Use

    Additional MCM6 Antibody Formats

    Formats Applications Sizes available
    MCM6 Antibody : Purified WB 0.1 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

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          Recommended Positive Controls

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