MALT1 Antibody | 50

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MALT1 Antibody | 50 gallery image 1

Stainig of paraffin embedded human tonsil stained with Mouse anti Human MALT1 (MCA2801GA)

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  • MALT1 Antibody | 50 thumbnail image 1
  • Mouse anti Human MALT1
  • Mouse anti Human MALT1
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  • Product Type
    Monoclonal Antibody
  • Clone
    50
  • Isotype
    IgG1
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA2801GAP *, WBdatasheet pdfdatasheet pdf0.1 mg
    MCA2801GA
    MCA2801P *, WBdatasheet pdfdatasheet pdf0.2 mg
    MCA2801
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Mouse anti Human MALT1 antibody, clone 50 recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), also known as MALT lymphoma-associated translocation and paracaspase. MALT1 is an 824 amino acid ~93kDa protein belonging to the peptidase C14B family containing a single death domain and two Ig-like CD-type domains. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB (Yang et al. 2013).

      MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas (Horsman et al. 1992), which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2 (Dierlamm et al. 1999). Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent. (Zhou et al. 2005)

      Mouse anti Human MALT1 recognizes both MALT1 and the MALT1-API2 fusion protein (Murga Penas et al. 2007).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting
      Immunohistology - Paraffin(1)1/251/100
      (1)
      This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting
      Immunohistology - Paraffin(1)1/251/100
      (1)
      This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Technical Advice
    • Recommended Protocol
    • Recommended Protocol
    • ELISA
    • ELISA
    • Immunohistology
    • Immunohistology
    • Histology Positive Control Tissue
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Immunofluorescence
    • Western Blotting
    • Western Blotting
    • Instructions For Use
    • Instructions For Use

    Additional MALT1 Antibody Formats

    Formats Clone Applications Sizes available
    MALT1 Antibody : Purified 50 P *, WB 0.2 mg | 0.1 mg
    • Copyright © 2016 Bio-Rad

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          Recommended Positive Controls

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              References

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