LRP6 Antibody

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Staining of formalin fixed, paraffin embedded huan liver with Rabbit anti Human LRP6 (AHP2044)

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  • Goat anti Human LRP6
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP2044E, Pdatasheet pdfdatasheet pdf50 µg
    AHP2044
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Goat anti Human LRP6 antibody recognizes human Low-density lipoprotein receptor-related protein 6 (LRP-6). LRP6 is a widely expressed 1594 amino acid ~:200 kDa single pass type I endoplasmic reticular transmembrane glycoprotein. LRP6 is released from the endoplasmic reticulum of palmitoylation.

      LRP6 is involved with Wnt Frizzled and LRP5 in the formation of signalosomes, inducing beta catenin signaling (Bilic et al. 2007).

      Mutations in the LRP6 gene can lead to development of Coronary artery disease, autosomal dominant, 2 (ADCAD2) a disease characterised by reduced or absent blood flow in one or more arteries supplying the heart which can in some cases lead to acute myocardial infarction (Mani et al. 2007).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      ELISA1:64000
      Immunohistology - Paraffin5ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
      This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
    • Histology Positive Control Tissue
      Human hepatocytes and bile duct
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional LRP6 Antibody Formats

    Formats Applications Sizes available
    LRP6 Antibody : Purified E, P 50 µg
    • Copyright © 2016 Bio-Rad

    Recommended Secondary Antibody

      DescriptionProduct CodePack SizeApplicationsList PriceQuantity
      Donkey anti Sheep/Goat IgG:HRPSTAR88P1 mlC, E, P, WB
      STAR88P

      Recommended Negative Isotype Control

        Useful Reagents

          DescriptionProduct CodePack SizeApplicationsList PriceQuantity
          Antigen Retrieval Buffer, pH8.0BUF025C50 mlP
          BUF025C
          Histar Detection SystemSTAR3000B150 TestsC, P
          STAR3000B
          Histar Detection SystemSTAR3000A50 TestsC, P
          STAR3000A
          Histar Detection SystemSTAR3000C500 TestsC, P
          STAR3000C
          Antigen Retrieval Buffer, pH8.0BUF025A500 mlP
          BUF025A

          Recommended Positive Controls

            Histology Controls

              Human hepatocytes and bile duct

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