Rabbit anti Human LRP6 antibody recognizes human Low density lipoprotein receptor related-protein 6 (LRP6), a 180.4 kDa single pass type 1 membrane protein belonging to the LDLR family.
LRP6 is an essential component of the Wnt/beta catenin signalling pathway where it is believed to act as a co-receptor with Frizzled for Wnt. It is a specific high affinity receptor for DKK1 and DKK2.
LRP6 is implicated in a wide range of normal and disease processes connected with lipid metabolism. It is co-expressed with LDR5 during embryogenesis and in adult tissues. Defects in LRP6 cause autosomal dominant coronary artery disease type 2.
Purified IgG - liquid
Antisera to human LRP6 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
0.09% Sodium Azide (NaN3)
A synthetic peptide corresponding to amino acids 1546-1560 of human LRP6 – conjugated to KLH
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Reagents In The Kit
Preparing The Antibody
Phosphate buffered saline
Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Immunohistology - Paraffin(1)
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.