Low Density Lipoprotein

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Published customer image:
Native low density lipoprotein (5685-3204) used as a control (-/-) for evaluation of MDL-1 protein levels following stimulation of peritoneal macrophages with oxidized LDL (5683-3557) by western blotting.
Image caption:
MDL-1 expression is regulated by pathophysiological agents implicated in atherosclerotic progression and regression in vitro. Western blot analyses of MDL-1 protein level in C57BL/6 mice peritoneal macrophages stimulated with 50 μg/mL ox-LDL with or without pretreatment with 100 µmol/L HIF-1α inhibitor. Values are expressed as mean ± SEM. *p<0.05; # p<0.01

From: Xiong W, Wang H, Lu L, Xi R, Wang F, Gu G, Tao R.
The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival.
J Transl Med. 2017 Nov 10;15(1):234.

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  • Native Human Low Density Lipoprotein
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  • Product Type
    Purified Protein
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    5685-3204FNdatasheet pdfdatasheet pdf5 mg
    5685-3204
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
    -
    • Low density lipoproteins transport cholesterol and triglycerides to cells requiring them. They are delivered via LDL receptors in the plasma membrane, via clathrin coated pits to the endosomal pathway for further processing.
    • Intended Use
    • Target Species
      Human
    • Product Form
      Purified from human plasma - liquid
    • Reconstitution
    • Preparation
      Purified via ultracentrifugation to homogeneity as determined via agarose gel electrophoresis.
    • Preservative Stabilisers
      0.3mM EDTA
    • Activity
      This lot of material has been evaluated for receptor binding to human skin fibroblasts in conjunction with Dil-LDL.
    • Purity
    • Approx. Protein Concentrations
      Total protein concentration 5.0 mg/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      TRIS buffered saline
    • Storage
      Store at +4oC. DO NOT FREEZE.
      This product should be stored undiluted. Precipitation may occur after prolonged storage. This is normal and can be removed by centrifugation. This product has been aseptically packaged and membrane filtered. Handle aseptically.
    • Shelf Life
      Please see label for expiry date.
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Functional Assays

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Low Density Lipoprotein Formats

    Formats Applications Sizes available
    Low Density Lipoprotein : Purified FN 5 mg
    • Copyright © 2017 Bio-Rad Antibodies (formerly AbD Serotec)

    Recommended Secondary Antibody

      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              References

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