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Inhibin Alpha Antibody

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  • Rabbit anti Human Inhibin Alpha
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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    0100-0549E, Pdatasheet pdfdatasheet pdf1 ml
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Rabbit anti Human inhibin alpha antibody recognizes the human inhibin alpha chain, the product of the INHA gene. The inhibin alpha chain is a 366 amino acid polypeptide with a predicted molecular weight of ~40kDa. It is composed of an N-terminal 18 amino acid signal peptide, two pro-peptide regions of 43 and 171 amino acids respectively and the 134 amino acid inhibin alpha chain. Inhibin alpha dimerizes with with inhibin beta A to form Inhibin A or with the inhibin beta B chain to form inhibin B. The active inhibin alpha chain is derived by cleavage of the inhibin alpha chain from the pro-peptide domains and subsequent dimerization through appropriate disulphide bond formation. Inhibins regulate follicle stimulating hormone secretion from the pituitary gland (Lumpkin et al. 1981).

      Inhibin alpha is expressed in the testis (Bergh and Cajander 1990) and ovary (Cuevas et al. 1987, Yamoto et al. 1992). Inhibin alpha expression has also been noted in the adrenal glands (McCluggage et al. 1998), endomertium (Mylonas et al. 2004) and brain (Uccella et al. 200). Inhibin alpha expression has also been noted in a variety of neooplastic tissues including Leydig cell tumors (de Winter et al. 1992), brain tumors (Demura et al. 1995), ovarian cancers (Cooke et al. 1995) and adrenal carcinomas (Pelkey et al. 1998).

      Rabbit anti human inhibin alpha antibody has been utilized successfully for the immunohistochemical localization of inhibin alpha in benign ovarian Brenner tumor (Kuhn et al. 2013).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Paraffin1/1001/500

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
      Human ovarian cortex
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Inhibin Alpha Antibody Formats

    Formats Applications Sizes available
    Inhibin Alpha Antibody : Purified E, P 1 ml
    • Copyright © 2016 Bio-Rad

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      Sheep anti Rabbit IgG:HRP (Multi Adsorbed)STAR541 mgC, E, WB
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      Recommended Negative Isotype Control

        Useful Reagents

          DescriptionProduct CodePack SizeApplicationsList PriceQuantity
          Antigen Retrieval Buffer, pH8.0BUF025C50 mlP
          Antigen Retrieval Buffer, pH8.0BUF025A500 mlP

          Recommended Positive Controls

            Histology Controls

              Human ovarian cortex


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