Heme Oxygenase 1 antibody
Rabbit anti Human Heme Oxygenase 1
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Heme Oxygenase 1
Rabbit anti Human heme oxygenase 1 antibody recognizes human heme oxygenase-1 (HO-1), a 288 amino acid enzyme with a crucial role in heme catabolism, cleaving the heme ring to form biliverdin which is further processed to form bilirubin by a reductase enzyme. HO-1 activity is highest in the spleen where it is involved in the processing of senescent erythrocytes (Delaby et al. 2012). HO-1 expression can be increased during cellular stress, including heat shock (Ewing et al. 1992). Baseline levels of expression are high in certain tissues, including spleen and liver. Enriched enzyme preparations are recommended for experimental analysis. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Bovine Mouse Rat Dog Pig - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.065% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide with the amino acid sequence HDLSEALKEATKEVHC corresponding to residues 12-25 (+C-NH2 of human heme oxygenase 1.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 6 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Frozen | 1/50 | 1/1000 | |
Western Blotting 1 | 1/1000 |
- 1This antibody detects a band of approximately 32kDa under reducing conditions.
- Histology Positive Control Tissue
- Human spleen
Human kidney
Porcine arteries
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml | Log in | |||
List Price | Your Price | ||||||
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Description | Sheep anti Rabbit IgG:RPE |
- Synonyms
- HO-1
- RRID
- AB_2295359
- UniProt
- P09601
- Entrez Gene
- HMOX1
- GO Terms
- GO:0001525 angiogenesis
- GO:0001935 endothelial cell proliferation
- GO:0002246 wound healing involved in inflammatory response
- GO:0002686 negative regulation of leukocyte migration
- GO:0004392 heme oxygenase (decyclizing) activity
- GO:0004871 signal transducer activity
- GO:0005615 extracellular space
- GO:0005789 endoplasmic reticulum membrane
- GO:0005792 microsome
- View More GO Terms
- GO:0006788 heme oxidation
- GO:0006879 cellular iron ion homeostasis
- GO:0006916 anti-apoptosis
- GO:0007243 intracellular protein kinase cascade
- GO:0007588 excretion
- GO:0008219 cell death
- GO:0045909 positive regulation of vasodilation
- GO:0014806 smooth muscle hyperplasia
- GO:0019899 enzyme binding
- GO:0020037 heme binding
- GO:0034101 erythrocyte homeostasis
- GO:0034383 low-density lipoprotein particle clearance
- GO:0035094 response to nicotine
- GO:0042167 heme catabolic process
- GO:0042542 response to hydrogen peroxide
- GO:0042803 protein homodimerization activity
- GO:0051260 protein homooligomerization
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
- GO:0045080 positive regulation of chemokine biosynthetic process
- GO:0045765 regulation of angiogenesis
- GO:0048661 positive regulation of smooth muscle cell proliferation
- GO:0048662 negative regulation of smooth muscle cell proliferation
- GO:0055085 transmembrane transport
4915-1050
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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