Haptoglobin antibody
Sheep anti Human Haptoglobin
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Haptoglobin
Sheep anti Human Haptoglobin antibody detects haptoglobin, also known as Hp, an acute phase plasma glycoprotein synthesized by the liver in response to infection or inflammation. Haptoglobin binds haemoglobin released by erythrocytes with high affinity, and functions to block the oxidative activity of haemoglobin and prevent renal damage. The haptoglobin-haemoglobin complex is rapidly removed from the circulation by monocytes and macrophages, via the receptor CD163. The haptoglobin genotype is an independent risk factor for cardiovascular disease (Levy et al>. 2002). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Native, purified human haptoglobin from serum.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
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ELISA |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Rabbit anti Sheep IgG (H/L):Biotin |
References for Haptoglobin antibody
-
Guetta, J. et al. (2007) Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin.
Atherosclerosis. 191: 48-53. -
Araki, H. et al. (2015) Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients.
Cancer Immunol Immunother. 64 (12): 1565-73. -
Soejima, M. et al. (2014) Genetic factors associated with serum haptoglobin level in a Japanese population.
Clin Chim Acta. 433: 54-7. -
Bucci, M. et al. (2012) Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo.
J Pharmacol Exp Ther. 340 (3): 716-22.
Further Reading
-
Carter, K. & Worwood, M. (2007) Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases.
Int J Lab Hematol. 29 (2): 92-110.
- RRID
- AB_618599
- UniProt
- P00738
- Entrez Gene
- HP
- GO Terms
- GO:0006952 defense response
- GO:0004252 serine-type endopeptidase activity
- GO:0005576 extracellular region
- GO:0006508 proteolysis
- GO:0006879 cellular iron ion homeostasis
- GO:0010942 positive regulation of cell death
- GO:0030492 hemoglobin binding
- GO:0051354 negative regulation of oxidoreductase activity
- GO:2000296 negative regulation of hydrogen peroxide catabolic process
- View More GO Terms
4890-0004
0315If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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