FYN Antibody (PrecisionAbTM Antibody)

FYN Antibody (PrecisionAb<sup>TM</sup> Antibody) gallery image 1

Western blot analysis of whole cell lysates probed with FYN antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 197 second exposure. Arrow points to FYN (molecular weight 61 kDa)

  • FYN Antibody (PrecisionAb<sup>TM</sup> Antibody) thumbnail image 1
  • FYN Antibody with Control Lysate
  • Mouse anti FYN
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    FYN antibody recognizes tyrosine-protein kinase FYN, also known as proto-oncogene Syn, proto-oncogene c-Fyn, Src-like kinase, SLK or p59-Fyn. The antibody has been extensively validated for western blotting using whole cell lysates.
    • Product Type
      PrecisionAb™ Monoclonal
    • Isotype
    • Format
      Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
      VMA00053WBdatasheet pdfdatasheet pdf100 µl
      VMA00053KTWBdatasheet pdfdatasheet pdf datasheet pdf2 Westerns
      Secondary Antibodies
      Negative Isotype Controls
      Useful Reagents
      Positive Controls
      Histology Controls
      • Mouse anti Human FYN antibody recognizes FYN, a member of the src family of non receptor protein tyrosine kinases, expressed by T-cells and natural killer (NK) cells, and highly expressed in brain.

        FYN plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T-cell receptor (TCR) eta chain/CD3 complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T-cell signaling cascade.

        Recent studies into Alzheimer’s disease have implicated FYN in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.

        Mouse anti Human FYN antibody recognizes FYN as a band of ~61 kDa in western blotting in multiple cell line lysates including myeloid, lymphoid, neuronal, adenocarcinoma, sarcoma and embryonic kidney.
      • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000

      • PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
      • Copyright © 2017 Bio-Rad Antibodies (formerly AbD Serotec)

      Recommended Secondary Antibody

        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Mouse IgG (H/L):HRPSTAR207P2 mlWB
        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Mouse IgG (H/L):HRPSTAR207P2 mlWB

        Recommended Negative Isotype Control

          Useful Reagents

            Recommended Positive Controls

              Histology Controls

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