Frataxin antibody
Rabbit anti Frataxin
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- Frataxin
Antibody Quality and Performance Guarantee
| Rabbit anti Human frataxin antibody recognizes frataxin, also known as Friedreich ataxia protein, FRDA and FXN. This nuclear gene encodes a mitochondrial protein thatfunctions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in the autosomal recessive inherited disease Friedreich ataxia. Alternative splicing results in multiple transcript variants (provided by RefSeq, Jun 2009). Rabbit anti Human frataxin antibody detects a band of 24 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti frataxin antibody recognizes a band of approximately 24 kDa in Raji cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
2% Sucrose - Immunogen
- Synthetic peptide corresponding to a portion of the C terminal segment of human frataxin
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- Q16595
- Entrez Gene
- FXN
- GO Terms
- GO:0005515 protein binding
- GO:0004322 ferroxidase activity
- GO:0005829 cytosol
- GO:0005759 mitochondrial matrix
- GO:0006783 heme biosynthetic process
- GO:0006826 iron ion transport
- GO:0006879 cellular iron ion homeostasis
- GO:0008198 ferrous iron binding
- GO:0008199 ferric iron binding
- View More GO Terms
- GO:0008284 positive regulation of cell proliferation
- GO:0010039 response to iron ion
- GO:0010722 regulation of ferrochelatase activity
- GO:0016540 protein autoprocessing
- GO:0018283 iron incorporation into metallo-sulfur cluster
- GO:0030307 positive regulation of cell growth
- GO:0034986 iron chaperone activity
- GO:0043066 negative regulation of apoptosis
- GO:0048554 positive regulation of metalloenzyme activity
- GO:0051347 positive regulation of transferase activity
- GO:0051349 positive regulation of lyase activity
- GO:0051353 positive regulation of oxidoreductase activity
- GO:0051537 2 iron, 2 sulfur cluster binding
- GO:0070301 cellular response to hydrogen peroxide
- GO:0090201 negative regulation of release of cytochrome c from mitochondria
VPA00877
170801
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