Exosome Component 9 Antibody

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Jurkat cell lysate probed with Goat anti Human exosome component 9 C-terminal (AHP2140)

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  • Goat anti Human Exosome Component 9 (C-Terminal)
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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP2140E, WBdatasheet pdfdatasheet pdf0.1 mg
    AHP2140
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • AHP2140 specifically recognises an epitope within the C-Terminal (CT) region of human Exosome component 9 (EXOSC9), otherwise known as PMSCL1.

      EXOSC9 is a member of the RNase PH family, and component of the exosome 3'->5' exoribonuclease (PM/Scl) complex, which exhibits exonuclease activity, and is involved in the degradation of unstable RNA, and the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA . EXOSC9 has been identified as an autoantigen in patients with the complex auto immune disease scleromyositis.
    • Intended Use
    • Target Species
      Human
    • Product Form
      Purified IgG - liquid
    • Reconstitution
    • Preparation
    • Antiserum Preparation
      Antiserum to human EXOSC9 (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
    • Preservative Stabilisers
      0.02% Sodium Azide (NaN3)
      0.5% Bovine Serum Albumin
    • Immunogen
      Synthetic peptide sequence C-RTQTTSAKQEKAP from the C-Terminal region of EXOSC9 (NP_001029366.1; NP_005024.2).
    • Purity
    • Approx. Protein Concentrations
      IgG concentration 0.5mg/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      TRIS buffered saline
    • Storage
      Store at +4oC or at -20oC if preferred.
      Storage in frost-free freezers is not recommended.
      This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • GO Terms
      rRNA processing
      3'-5'-exoribonuclease activity
      RNA binding
      immune response
      nuclear exosome (RNase complex)
      cytosol
      protein binding
      exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
      nucleolus
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      ELISA1/64000
      Western Blotting0.31.0ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
      AHP2140 detects a band of approximately 75kDa in Jurkat cell lysates.
    • Instructions For Use

    Additional Exosome Component 9 Antibody Formats

    Formats Applications Sizes available
    Exosome Component 9 Antibody : Purified E, WB 0.1 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

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