EMR3 antibody | 3D7
Hamster anti Human EMR3
- Product Type
- Monoclonal Antibody
- Clone
- 3D7
- Isotype
- IgG
- Specificity
- EMR3
Hamster anti Human EMR3 antibody, clone 3D7 recognizes human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 (EMR3), a ~56 kDa member of the EGF-7 transmembrane (TM7) family of adhesion receptors. EMR3 is expressed at the cell surface as a heterodimer. EMR3 is predominantly expressed on granulocytes, and at lower levels on mature myeloid cells, monocytes and dendritic cells. EMR3 is absent on lymphocytes, haematopoietic stem cells and myeloid progenitors. EMR3 is up-regulated during late stages of neutrophil differentiation and is a marker for terminally differentiated cells (Matmati et al.2007). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide - Carrier Free
- Yes
- Immunogen
- ARHO-EMR3-CD97 (EGF1) transfectants.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized Armenian hamster were fused with cells of the mouse SP2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | 1/50 | 1/200 | |
Immunoprecipitation |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Hamster (Armenian) IgG Negative Control | MCA2356 | F | 0.25 mg | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Hamster (Armenian) IgG Negative Control |
Source Reference
-
Matmati, M. et al. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.
J Leukoc Biol. 81 (2): 440-8.
References for EMR3 antibody
-
Drewniak, A. etal. (2009) Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes.
Blood. 113: 5979-98. -
Gazendam, R.P. et al. (2016) Impaired killing of Candida albicans. by granulocytes mobilized for transfusion purposes: a role for granule components.
Haematologica. 101 (5): 587-96. -
van de Geer, A. et al. (2017) Characterization of buffy coat-derived granulocytes for clinical use: a comparison with granulocyte colony-stimulating factor/dexamethasone-pretreated donor-derived products.
Vox Sang. 112 (2): 173-82. -
Hansen, M. et al. (2018) Efficient production of erythroid, megakaryocytic and myeloid cells, using single cell-derived iPSC colony differentiation.
Stem Cell Res. 29: 232-44.
Further Reading
-
Carpenter, G. & Cohen, S. (1990) Epidermal growth factor.
J Biol Chem. 265 (14): 7709-12.
- RRID
- AB_872003
- UniProt
- Q9BY15
- Entrez Gene
- EMR3
- GO Terms
- GO:0005886 plasma membrane
- GO:0005509 calcium ion binding
- GO:0016021 integral to membrane
- GO:0004930 G-protein coupled receptor activity
- GO:0005615 extracellular space
- GO:0007218 neuropeptide signaling pathway
MCA2476GA
149332If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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