Cyclophilin B antibody
KO Validated
Rabbit anti Cyclophilin B
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- Cyclophilin B
Antibody Quality and Performance Guarantee
| Rabbit anti Human cyclophilin B antibody recognizes cyclophilin B also known as peptidyl-prolyl cis-trans isomerase B, PPIB, PPIase B, S-cyclophilin, cyclophilin-like protein, epididymis secretory protein Li 39, peptidyl-prolyl cis-trans isomerase B, rotamase B or SYP-S1. The protein encoded by PPIB gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporin A-mediated immunosuppression (provided by RefSeq, Oct 2009). Mutations in the PBIB gene lead to development of Osteogenesis imperfecta 9 (OI9) , a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma (van Dijk et al. 2009). Rabbit anti Human cyclophilin B antibody detects a band of 20 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti cyclophilin B detects a band of approximately 20 kDa in A431 cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the C terminal region of human cyclophilin B
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml.
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- P23284
- Entrez Gene
- PPIB
- GO Terms
- GO:0051082 unfolded protein binding
- GO:0006457 protein folding
- GO:0003755 peptidyl-prolyl cis-trans isomerase activity
- GO:0005788 endoplasmic reticulum lumen
- GO:0042277 peptide binding
- GO:0042470 melanosome
VPA00583
160801
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