Complement Factor H antibody | OX-24
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Mouse anti Human Complement Factor H
- Product Type
- Monoclonal Antibody
- Clone
- OX-24
- Isotype
- IgG1
- Specificity
- Complement Factor H
Antibody Quality and Performance Guarantee
| Mouse anti Human Complement Factor H antibody, clone OX-24 recognizes the human serum complement protein factor H (155 kDa), binding to a different epitope from MRC OX23. The antibody also recognizes a 43-49 kDa truncated form of factor H present at low level (1-5 μg/ml) in plasma and urine. In an immunoprecipitation system, it recognizes factor H in other primates, but not in cow, sheep, pig, chicken or rabbit sera. Mouse anti Human Complement Factor H antibody, clone OX-24 inhibits the binding of factor H to surface bound C3b, and recognizes Factor H in Western blotting procedures. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide - Carrier Free
- Yes
- Immunogen
- Human complement factor H.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- NS-0 myeloma fused with spleen cells from BALB/c mice.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Flow Cytometry | |||
| Immunoprecipitation | |
||
| Western Blotting | |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Source Reference
-
Sim, E. et al. (1983) Monoclonal antibodies against the complement control protein factor H (beta 1 H).
Biosci Rep. 3 (12): 1119-31.
References for Complement Factor H antibody
-
Alsenz, J. et al. (1985) Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H.
Biochem J. 232 (3): 841-50. -
Fontaine, M. et al. (1989) Truncated forms of human complement factor H.
Biochem J. 258 (3): 927-30. -
Kelly, U. et al. (2010) Heparan Sulfate, Including That in Bruch's Membrane, Inhibits the Complement Alternative Pathway: Implications for Age-Related Macular Degeneration.
J Immunol. 185: 5486-94. -
Johnson, S.A. et al. (2010) Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome-A pedigree revisited.
Mol Immunol. 47 (7-8): 1585-91. -
Hamidov, Z. et al. (2011) Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma.
J Clin Pathol. 64 (11): 990-4. -
Gurjar, B.S. et al. (2018) Characterization of genetic predisposition and autoantibody profile in atypical haemolytic-uraemic syndrome.
Immunology. 154(4):663-72.
MCA509G
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