CHI3L1 Antibody | C02-4H12

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  • Mouse anti Human CHI3L1
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  • Product Type
    Monoclonal Antibody
  • Clone
    C02-4H12
  • Isotype
    IgG2b
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA5962GAEdatasheet pdfdatasheet pdf0.1 mg
    MCA5962GA
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
    -
    • Mouse anti Human CHI3L1, clone C02-4H12, recognizes human CHI3L1 (also known as HCgp39 & YKL-40). CHI3L1 is a secreted glcoprotein belonging to the family of chitinase-like lectins but lacking enzymatic properties.

      CHI3L1 is produced by smooth muscle cells, macrophages, neutrophils, chondrocytes and osteosarcoma cels. While the general mode of action remains to determined, CHI3L1 has been implicated in angiogenesis via VEGF signalling (Riabov et al. 2014). CHI3L1 has aslo emerged as a biomarker of many chronic inflammatory conditions such as Alzheimer`s disease (Craig-Schapiro et al. 2010), rheumatoid arthritis (Lee et al. 2011) and multiple sclerosis (Comabella et al. 2010).
    • Intended Use
    • Target Species
      Human
    • Product Form
      Purified IgG - liquid
    • Reconstitution
    • Preparation
      Purified IgG prepared by affinity chromatography on Protein G from ascites
    • Preservative Stabilisers
      0.09% Sodium Azide (NaN3)
    • Immunogen
      E. coli derived recombinant protein corresponding to aa 22-383 of human CHI3L1/YKL-40
    • Purity
    • Approx. Protein Concentrations
      IgG concentration 1.0 mg/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      Phosphate buffered saline
    • Fusion Partners
      Spleen cells from immunised BALB/c mouse were fused with cells of the mouse myeloma SP2/0 cell line
    • Storage
      Store at +4oC or at -20oC if preferred.
      Storage in frost-free freezers is not recommended.
      This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • GO Terms
      sugar binding
      extracellular matrix structural constituent
      extracellular space
      chitinase activity
      chitin catabolic process
      proteinaceous extracellular matrix
      cation binding
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      ELISA

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional CHI3L1 Antibody Formats

    Formats Clone Applications Sizes available
    CHI3L1 Antibody : Purified C02-4H12 E 0.1 mg
    • Copyright © 2016 Bio-Rad

    Recommended Secondary Antibody

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              Further Reading

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