CD41 Antibody | MM2/356

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Staining of human peripheral blood platelets with Mouse anti Human CD41 (MCA468S)

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  • CD41 Antibody | MM2/356 thumbnail image 1
  • Mouse anti Human CD41
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Monoclonal Antibody
  • Clone
    MM2/356
  • Isotype
    IgG2b
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA468SF, IPdatasheet pdfdatasheet pdf2 ml
    MCA468S
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Mouse anti Human CD41 antibody, clone MM2/356 recognises human Integrin alpha-IIb, also known as CD41 or Platelet membrane glycoprotein IIb. CD41 is a 1039 amino acid, including a 31 amino acid signal peptide ~115 kDa single pass type 1 transmembrane glycoprotein expressed by platelets and megakaryocytes. CD41 is involved in the rapid repair of endothelial integrity following injury, causing platelet aggregation through soluble fibrinogen binding and physically plugging the injured endothelial surface (Simon et al. 2011).

      Mutations in the ITGA2B gene can lead to the development of coagulation disorders including Glanzmann thrombasthenia (GT), an inherited disease of platelet aggregation characterized by mucocutaneous bleeding (Wilcox et al. 1995) and Bleeding disorder, platelet-type 16 (BDPLT16), a congenital macrothrombocytopenia associated with platelet anisocytosis (Kunishima et al. 2011).
    • Intended Use
    • Target Species
      Human
    • Species Cross-Reactivity
      Target SpeciesCross Reactivity
      Pigyes
      Minkyes
      Mustelidyes
      N.B. Antibody reactivity and working conditions may vary between species.
    • Product Form
      Tissue Culture Supernatant - liquid
    • Reconstitution
    • Preparation
      Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum
    • Preservative Stabilisers
      0.09%Sodium Azide
    • Immunogen
      Human platelet membranes.
    • Purity
    • Approx. Protein Concentrations
      IgG concentration 10 ug/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      None present
    • Fusion Partners
      Spleen cells from immunised mice were fused with cells of the SP2/0 mouse myeloma cell line.
    • Storage
      Store at +4oC or at -20oC if preferred.

      This product should be stored undiluted.

      Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • GO Terms
      identical protein binding
      platelet alpha granule membrane
      integrin complex
      receptor activity
      platelet activation
      platelet degranulation
      axon guidance
      integrin-mediated signaling pathway
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Flow CytometryNeat
      Immunoprecipitation

    • Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • Flow Cytometry
      Use 10ul of the suggested working dilution to label 106 cells in 100ul.
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional CD41 Antibody Formats

    Formats Clone Applications Sizes available
    CD41 Antibody : S/N MM2/356 F, IP 2 ml
    • Copyright © 2016 Bio-Rad Antibodies (formerly AbD Serotec)

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        Useful Reagents

          Recommended Positive Controls

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              References

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