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Caveolin 1 Antibody

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  • Goat anti Caveolin 1

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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP1058E, WBdatasheet pdfdatasheet pdf0.1 mg
    AHP1058
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Goat anti Human Caveolin 1 antibody recognizes human caveolin-1, a 178 amino acid, ~21kDa membrane associated protein. Caveolin 1 is a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types (Anderson 1998). Two isoforms of caveolin are generated by alternative initiation, they differ in their N-terminal region with caveolin 1β lacking amino acids 1-31 present in caveolin 1α (Vainonen et al. 2004). Goat anti Human caveolin 1 antibody recognizes epitopes within the region between amino acids 34-41 of caveolin 1α and is therefore expected to recognize both isoforms of caveolin 1

      Caveolin1 is highly expressed in terminally differentiated or quiescent cells, suggesting a possible role for caveolin 1 as a negative regulator of cell proliferation (Galbiati et al.2001).

      Caveolin1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis (Núñez-Wehinger et al. 2014).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      ELISA1/32,000
      Western Blotting0.31.0ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
      AHP1058 detects a band of approximately 21Da and 25kDa in human heart, lung and spleen lysates.
    • Instructions For Use

    Additional Caveolin 1 Antibody Formats

    Formats Applications Sizes available
    Caveolin 1 Antibody : Purified E, WB 0.1 mg
    • Copyright © 2017 Bio-Rad Antibodies (formerly AbD Serotec)

    Recommended Secondary Antibody

      DescriptionProduct CodePack SizeApplicationsList PriceQuantity
      Rabbit anti Goat IgG (Fc):FITCSTAR122F1 mgF
      STAR122F
      Rabbit anti Goat IgG (Fc):HRPSTAR122P1 mgC, E, WB
      STAR122P

      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              • Application NameReference Images
                Western Blotting

              References

              1. Hommel, A. et al. (2010) The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis.
              Mol Cell Biol. 30: 1231-42.

              Further Reading

              1. Williams, T.M. and Lisanti, M.P. (2005) Caveolin-1 in oncogenic transformation, cancer, and metastasis.
              Am. J. Physiol. Cell. Physiol. 288: 494-506.
              2. Liu, P. et al. (2002) Multiple functions of caveolin-1.
              J. Biol. Chem. 277: 41295-41298.

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