Immunohistochemical localization of casein kinase 1 delta to granular lesions in the hippocampus of a patient with Alzheimer's disease using Goat anti Human casein kinase 1 delta antibody (AHP796) on formalin dixed, paraffin embedded tissue sections
Goat anti Human Casein Kinase 1 Delta (C-Terminal)
1 Formats Available
E, P *
Negative Isotype Controls
Goat anti Human casein kinase 1 delta antibody recognizes human casein kinase 1 delta, also known as protein kinase CK1 delta or Tau-protein kinase CSNK1D.
Casein kinase 1 delta is a 415 amino acid ~47 kDa member of the casein kinase 1 family of protein kinases common to all eukaryotic cells, although tissue distribution and subcellular localisation may vary between isoforms. Casein kinase 1 delta has been implicated in the regulation of p53 (Venerando et al. 2010). Upregulation of casein kinase 1 delta expression has been reported in Alzheimer's disease hippocampus and its association with tau-containing bodies suggests that it may play a role in the abnormal phosphorylation of tau (Li et al. 2005).
Serum - liquid
Antisera to human casein kinase 1 delta were raised by repeated immunisations of goats with highly purified antigen.
Synthetic peptide corresponding to amino acids 310-327 of human casein kinase 1 delta
Approx. Protein Concentrations
Reagents In The Kit
Preparing The Antibody
Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Immunohistology - Paraffin(1)
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.