Beta Amyloid Antibody

Beta Amyloid Antibody gallery image 1

Published customer image:
Rabbit anti Beta amyloid antibody (AHP677) used for the demonstration of total amyloid load in mouse brain by immunohistochemistry on free floating tissue sections.
Image caption:
Total Aß load is reduced following intracranial administration of intact anti-Aβ antibody and deglycosylated anti-Aβ antibody. Panels B, D, and F show total Aβ immunostaining in the left (untreated) hippocampal regions of 20 mo. old APP transgenic mice. Panels A, C, and E show total Aβ staining in right hippocampal regions of 20 mo. old APP transgenic mice receiving intracranial injection of control antibody (panel A) or anti-Aβ C-terminal antibody (2H6; panel C), or deglycosylated anti-Aβ C-terminal antibody (de-2H6; panel E). Magnification = 40×, scale bar = 50 mm. Panel G shows quantification of the Aß load as the ratio of injected (right) side to uninjected (left) side for both the hippocampal and frontal cortical injection sites * indicates P<0.05 compared to mice injected with control IgG.

From: Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D.
Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice.
J Neuroinflammation. 2006 May 10;3:11.

  • Beta Amyloid Antibody thumbnail image 1
  • Rabbit anti Human Beta Amyloid (aa1-42)
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP677C, E, P*, WBdatasheet pdfdatasheet pdf0.1 ml
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Rabbit anti Human beta amyloid antibody recognises the beta amyloid (1-42) peptide, the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease (Benveniste et al. 2015). Beta amyloid also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy (Kirshner et al. 2015).

      Rabbit anti Human beta amyloid antibody (AHP677) may be used in immunohistochemical staining of Alzheimer's disease plaques.
    • Intended Use
    • Target Species
    • Product Form
      Serum - liquid
    • Reconstitution
    • Preparation
    • Antiserum Preparation
      Antisera to Beta amyloid (1-42) were raised by repeated immunisations of rabbits with highly purified antigen.
    • Preservative Stabilisers
      0.02%Sodium Azide
    • Purity
    • Approx. Protein Concentrations
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
    • Storage
      Store at +4oC or at -20oC if preferred.

      This product should be stored undiluted.

      Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Frozen
      Western Blotting1/5001/1000
      Immunohistology - Paraffin(1)
      This product requires formic acid pre-treatment of paraffin sections.

    • Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
      Alzheimer's disease brain
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Beta Amyloid Antibody Formats

    Formats Applications Sizes available
    Beta Amyloid Antibody : Serum C, E, P*, WB 0.1 ml
    • Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)

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      Recommended Negative Isotype Control

        Useful Reagents

          DescriptionProduct CodePack SizeApplicationsList PriceQuantity
          TidyBlot™ Western Blot Detection Reagent:HRPSTAR209P0.5 mlWB*

          Recommended Positive Controls

            Histology Controls

              Alzheimer's disease brain
              • Application NameReference Images
                Immunohistology - Frozen


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