ATR Antibody | 1E9

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ATR Antibody | 1E9 gallery image 1

Staining of paraffin-embedded human placenta with Mouse anti Human ATR (MCA5513Z)

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  • ATR Antibody | 1E9 thumbnail image 1
  • Mouse anti Human ATR:Preservative Free
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Monoclonal Antibody
  • Clone
    1E9
  • Isotype
    IgG1
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA5513ZPdatasheet pdfdatasheet pdf0.1 mg
    MCA5513Z
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
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    References
    Reviews
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    • Mouse anti Human ATR antibody, clone 1E9 recognizes human Serine/threonine-protein kinase ATR, also known as Ataxia telangiectasia and Rad3-related protein or FRAP-related protein 1. ATR is a 2644 amino acid ~300 kDa serine/threonine protein kinase involved in checkpoint signaling following cellular damage upon exposure to stressors such as ionizing radiation or DNA rplication failure. ATR is ubiquitously expressed with notably high lavels of expression in the testis.

      Mutations in the ATR gene can lead to presentation of developmental disorders including Seckel syndrome 1 (SCKL1), a recessive disorder characterized by prenatal onset dwarfism, microcephaly and mental retardation (O'Driscoll et al. 2003) and Cutaneous telangiectasia and cancer syndrome, familial (FCTCS), a condition presenting with infantile cutaneous telangiectases, patchy alopecia and abnormal nail, tooth and eyebrow development, along with increased risk of oropharyngeal malignancies (Tanaka et al. 2012).
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Paraffin0.110 ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional ATR Antibody Formats

    Formats Clone Applications Sizes available
    ATR Antibody : Preservative Free 1E9 P 0.1 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

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