Apolipoprotein H antibody | ID2
Mouse anti Human Apolipoprotein H
- Product Type
- Monoclonal Antibody
- Clone
- ID2
- Isotype
- IgG1
- Specificity
- Apolipoprotein H
Antibody Quality and Performance Guarantee
| Mouse anti Human apolipoprotein H antibody, clone ID2 recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome. |
- Target Species
- Human
- Product Form
- Tissue culture supernatant - liquid
- Preservative Stabilisers
- < 0.1% sodium azide (NaN3)
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Frozen |  |
||
| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human placenta
Source Reference
-
Chamley, L.W. et al. (2001) Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?
Fertil Steril. 76 (4): 700-6.
References for Apolipoprotein H antibody
-
Mak, I.Y. et al. (2002) Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro.
J Clin Endocrinol Metab. 87 (6): 2581-8. -
Vlachoyiannopoulos, P.G. et al. (2004) Anti-CD40 antibodies in antiphospholipid syndrome and systemic lupus erythematosus.
Thromb Haemost. 92: 1303-11. -
Lopez, D. et al. (2004) Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies to oxLig-1/beta2-glycoprotein I in patients with systemic lupus erythematosus and antiphospholipid syndrome.
Am J Clin Pathol. 121 (3): 426-36. -
Goonetilleke, U.R. et al. (2012) Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis.
mBio. 3 (2): e00272-11
- Synonyms
- Beta 2 Glycoprotein 1
- RRID
- AB_2058273
- UniProt
- P02749
- Entrez Gene
- APOH
- GO Terms
- GO:0001937 negative regulation of endothelial cell proliferation
- GO:0001948 glycoprotein binding
- GO:0005543 phospholipid binding
- GO:0006641 triglyceride metabolic process
- GO:0007597 blood coagulation, intrinsic pathway
- GO:0008201 heparin binding
- GO:0009986 cell surface
- GO:0010596 negative regulation of endothelial cell migration
- GO:0016525 negative regulation of angiogenesis
- View More GO Terms
- GO:0030195 negative regulation of blood coagulation
- GO:0031639 plasminogen activation
- GO:0033033 negative regulation of myeloid cell apoptosis
- GO:0034197 triglyceride transport
- GO:0034361 very-low-density lipoprotein particle
- GO:0034364 high-density lipoprotein particle
- GO:0034392 negative regulation of smooth muscle cell apoptosis
- GO:0042627 chylomicron
- GO:0043499 eukaryotic cell surface binding
- GO:0051006 positive regulation of lipoprotein lipase activity
- GO:0051918 negative regulation of fibrinolysis
- GO:0060230 lipoprotein lipase activator activity
MCA2114
160129
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