Angiogenin Antibody | MANG-1

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  • Mouse anti Human Angiogenin
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  • Product Type
    Monoclonal Antibody
  • Clone
  • Isotype
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    0555-5008C, E, P*datasheet pdfdatasheet pdf0.15 mg
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Mouse anti Human Angiogenin anibody, clone MANG-1 is a monoclonal antibody specific for angiogenin, a potent angiogenesis inducing polypeptide of approximately 16.5kDa responsible for inducing vascularization in both normal and malignant tissues through activation of vascular endothelium and smooth muscle cells ant triggering a number of processes including Cell migration and proliferation (Reviewed in Gao et al.2008) Angiogenin, also known as ribonuclease 5 demonstrates tRNA specific ribonuclease activity (Saxena et al. 1992), this in turn is regulated by binding to the ribonuclease inhibitor RNH1 (Tuefel et al. 2003) . Angiogenin exerts its vascular stimulation potential through binding to cytoplasmic actin on the surface of endothelial cells, followed by endocytosis and subsequent translocation to the nucleus

      Mouse anti Angiogenin, clone MANG1 stains single cells on human tonsil sections and endothelial cells in human terminal placenta. MANG-1 also demonstrates intense staining on carcinoma cells and of endothelial cells in intratumoral vessels (Marioni et al. 2010)
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Frozen1/60
      Immunohistology - Paraffin(1)1/30
      Proteinase K pretreatment for antigen retrieval is recommended for use with paraffin sections.See Marioni et al. 2011

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
      Human tonsil
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Angiogenin Antibody Formats

    Formats Clone Applications Sizes available
    Angiogenin Antibody : S/N MANG-1 C, E, P* 0.15 mg
    • Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)

    Recommended Secondary Antibody

      DescriptionProduct CodePack SizeApplicationsList PriceQuantity
      Goat anti Mouse IgG/A/M:Alk. Phos.STAR87A1 mgC, E, WB
      Goat anti Mouse IgM:Alk. Phos.(Human Adsorbed)STAR138A1 mlC, E, P, WB
      Human anti Mouse IgM:FITCHCA040F0.1 mgF
      Human anti Mouse IgM:HRPHCA040P0.1 mgE
      Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)STAR87P1 mgE
      Goat anti Mouse IgM:RPESTAR86PE0.5 mlF

      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              Human tonsil
              • Application NameReference Images
                Immunohistology - Paraffin


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