Goat anti advanced glycated end products antibody recognizes a variety of advanced glycated end product (AGE) epitopes. Glycation is the post-translational modification of proteins, linking a reducing sugar to an amino group on a protein. AGEs are thought to be involved in structural and functional alterations of proteins observed in aging and diabetes. AGEs recognised by Goat anti advanced glycated end products antibody (AHP1250) include carboxymethyllysine and pentosidine. Increases in pentosidine levels are associated with aging, diabetes, cataracts, renal diseases, chronic rheumatoid arthritis, photaged skin and Alzheimer's disease. Carboxymethyllysine is involved in uremia (Degenhardt et al. 1997).
Serum - liquid
Antisera to advanced glycated end products were raised by repeated immunisations of goats with highly purified antigen.
Sodium Azide (NaN3)
Glycated modified protein.
Approx. Protein Concentrations
Reagents In The Kit
Preparing The Antibody
Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
18 months from date of despatch.
For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Instructions For Use
Additional Advanced Glycated End Products Antibody Formats
1. Farboud, B. et al. (1999) Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye. Mol. Vis. 5:11.