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Mouse anti Guinea Pig CD4 antibody, clone CT7 used for the detection of CD4 expressing cells in the guinea pig airway by immunohistochemistry on formalin fixed, paraffin embedded sections.
Immunohistochemistry staining for CD4+ cells was not increased in animals neonatally sensitized compared with control animals. Representative slides of airway sections from adult animals immunostained for CD4+ cells are shown in the top and middle panels. The arrow shows an area of the epithelium with intense positive staining for CD4. Computerized quantification of CD4+ staining, expressed as % area of the airway wall, in control guinea pigs and animals sensitized at birth is shown in the bottom panel as means and standard errors, n = 5, n = 5, and n = 5 for 1-week, 3-week, and adult control animals, n = 5, n = 6, and n = 5 for 1-week, 3-week, and adult sensitized animals, respectively. A significant reduction was observed in the tissue of the 3-week-sensitized group compared to 3-week controls (P < 0.05).
From: Chitano P, Wang L, Degan S, Worthington CL, Pozzato V, Hussaini SH, Turner WC, Dorscheid DR, Murphy TM. Ovalbumin sensitization of guinea pig at birth prevents the ontogenetic decrease in airway smooth muscle responsiveness.
Physiol Rep. 2014 Dec 11;2(12). pii: e12241.