Bio-Rad offers a variety of antibodies and proteins for analyzing oncoproteins. For your convenience, we have grouped our oncoprotein research reagents into the four main oncoprotein classes (cell signaling proteins, growth factors, growth factor receptors and transcription factors) and highlighted our highly trusted anti-Bcl-2 and anti-H-Ras antibodies.
The apoptosis regulator Bcl-2 oncoprotein plays an important role in the decision of whether a cell lives or dies. It acts by controlling the permeability of the outer mitochondrial membrane.
Murine anti-Bcl-2 antibody (clone 100) is frequently used in Immunohistochemistry experiments and has been successfully used to demonstrate the presence of Bcl-2 in tissues of radioresistant squamous cell carcinoma (Condon et al. 2002).
The Ras protein family encompasses three members HRAS, NRAS and KRAS.
The genes encoding these proteins present some of the best studied proto-oncogenes, which upon mutation are involved in inducing various cancer types (including bladder, cervical, pancreatic and prostate).
Murine anti-human H-Ras antibody (MCA2884) is frequently used in Western blotting experiments and has been successfully used for the detection of H-Ras in human epitheliod breast cancer cells (MCF10A) (Vuoriluoto et al. 2011).
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