In the second part of our series on SUMOylation, we examine how key cell signaling proteins are regulated by SUMOylation, the effect of their aberrant SUMOylation on signaling pathways and the potential of SUMO inhibitors in cancer therapy.
Epidermal growth factor receptor (EGF R) is the most extensively studied receptor tyrosine kinase. In this blog we examine the history of EGF R, the EGF R family and its function along with how EGF R promotes cancer development.
Diabesity refers to the link between obesity and type 2 diabetes. This blog post describes the latest scientific findings describing the mechanism behind the failure of beta cells to proliferate in patients with type 2 diabetes, which could lead to novel treatments for this disease.