Negative Isotype Controls
- Chlamydia trachomatis is a nonmotile, Gram-negative human pathogen. It undergoes a unique biphasic developmental cycle, forming elementary bodies extracellularly and distinctive intracellular inclusions. The elementary body is infectious but metabolically inactive, cannot replicate and lacks detectable peptidoglycan. The major outer membrane protein (MOMP) comprises a large percentage of the outer membrane and is a transmembrane protein with type, species and genus reactive epitopes. The outer membrane also carries a heat stable lipopolysaccharide containing the reactive epitopes used for genus specific serological tests. There is structural similarity and antigenic cross-reactivity between chlamydial and other Gram-negative LPS moieties.
Chlamydia trachomatis is a common sexually transmitted bacterium. Chlamydia infection may cause proctitis, urethritis, trachoma (an eye infection and the leading cause of blindness worldwide) and infertility in both sexes. Prostatitis and epididymitis may occur in men and in women infection might lead to acute or chronic pelvic pain, pelvic inflammatory disease, cervicitis and ectopic pregnancy. In neonates the pathogen may cause trachoma and pulmonary complications.
PIP004 contains a high concentration of elementary bodies and chlamydial components in phosphate buffered saline. Residual host cellular material is present.
Inactivated Chlamydia trachomatis - liquid.
Mouse L cells are infected with C. trachomatis elementary bodies. Optimally infected cells are harvested and disrupted by sonication in phosphate bufffered saline. Cellular debris is removed by centrifugation.
The antigen preparation is inactivated using gamma radiation, which primarily damages chlamydial genetic material.
Chlamydia trachomatis LGV type II strain 434 cultured in mouse L cells.
This product has been rendered inactive by standard procedures. However this material should still be handled as infectious and should be disposed of appropriately.
Approx. Protein Concentrations
Total protein concentration 4.9 mg/ml
Reagents In The Kit
Preparing The Antibody
Phosphate buffered saline
Store at -70oC.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.
18 months from date of despatch.
For research purposes only
Additional Chlamydia trachomatis Formats
Recommended Secondary Antibody
Recommended Negative Isotype Control
Recommended Positive Controls