EGF R (L858R Mutant) antibody | RM380
Rabbit anti EGF R (L858R Mutant)
- Product Type
- Monoclonal Antibody
- Clone
- RM380
- Isotype
- IgG
- Specificity
- EGF R (L858R Mutant)
Antibody Quality and Performance Guarantee
| Rabbit anti EGF R (L858R mutant) antibody recognizes epidermal growth factor receptor (EGF R), also known as ERBB1 and HER1, mutated at the residue L858R. EGF R is a member of the ErbB family of receptor tyrosine kinases (RTKs) involved with activation of multiple signaling pathways including Ras/MAPK, PI3K/AKT, and PKC signaling (Sigismund et al. 2018). The EGF R plasma membrane receptor achieves this effect by binding to a range of extracellular growth factors, undergoing a conformational change, and transducing intracellular signaling (Liu et al. 2017). EGF R was one of the first identified oncogenes, and overexpression of EGF R has been reported in many human malignancies. The EGF R inhibitors gefitinib and erlotinib are used for treatment of advanced non-small cell lung cancer (NSCLC) (Bethune et al. 2010). The L858R activating mutation is a single-point substitution mutation in EGF R and is common in NSCLC. It is associated with decreased sensitivity to gefitinib and erlotinib (Gazdar, 2010). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the the EGF R L858R mutant
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/100 | 1/200 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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|---|---|---|---|---|---|---|---|
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
MCA6370
157632
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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